Assessing the use of antibiotics in pediatric patients hospitalized for varicellaArticle Published on 2022-12-122023-05-31 Journal: Italian Journal of Pediatrics [Category] 두창, 수두, 홍역, [키워드] antibiotic antimicrobial resistance children cost Hospitalization varicella. [DOI] 10.1186/s13052-022-01393-5 PMC 바로가기
Virtual screening of quinoline derived library for SARS-COV-2 targeting viral entry and replicationArticle Published on 2022-11-012022-11-15 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제, [키워드] added antibiotic antimalarial Antiviral approved binding domain Bruton tyrosine kinase inhibitors China claimed contagious Control country COVID-19 pandemic Dependent disease domain drug drug design FDA in viral in-depth analysis increase Infection inhibiting inhibitor Interaction interfere M pro MD simulation number of infected outbreak Papain Population protease provide Psychological distress quinoline based FDA approved Drugs. RBD Remdesivir Replication required resource RNA RNA dependent RNA polymerase RNA polymerase RNA virus SARS-CoV-2 selected Spike protein spread to target Vaccines viral entry viral replication Virtual screening [DOI] 10.1080/07391102.2021.1913228 PMC 바로가기
Self-sampling to identify pathogens and inflammatory markers in patients with acute sore throat: Feasibility studyArticle Published on 2022-10-062022-11-15 Journal: Frontiers in Immunology [Category] 바이오마커, 치료기술, [키워드] Analysis antibiotic Antibiotics approach Asymptomatic Bacterial bacterial pathogen benefit Biomarker Biomarkers children Concentration demonstrated detectable determine develop distribution Evidence Feasibility study feasible group help high risk identify Infection Inflammatory Inflammatory marker inflammatory markers media medium online tool Oropharyngeal participant pathogen Patient PCR PCR testing positive prevalence rates recruited reduce returned Saliva Self-swab sore sore throat sore throat diagnosis Support Swab swabs swabs. symptomatic and asymptomatic symptomatic participants tested throat swab Typical viral pathogen virus Volume [DOI] 10.3389/fimmu.2022.1016181 PMC 바로가기
Amikacin-loaded niosome nanoparticles improve amikacin activity against antibiotic-resistant Klebsiella pneumoniae strainsArticle Published on 2022-10-032022-11-16 Journal: World journal of microbiology & biotechnology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Amikacin analyzed antibiotic Antibiotic-resistance Antibiotics Bacteria Bacterial infection Bacterial infections calculated Cell cholesterol Concentration Coverage cytotoxicity drug resistance drug-resistant evaluated Gene Expression highest hospitalized patients IMPROVE inhibited Klebsiella Klebsiella pneumoniae less MBC MDR mechanism mRNA expression multi-drug resistant Niosome Niosome. occur positive ranged reduced SARS-CoV-2 significantly Spread stability strain Strains Toxicity Treatment were measured [DOI] 10.1007/s11274-022-03405-2 PMC 바로가기
Antibiotic prescribing trends in the US during the first 11 months of the COVID-19 pandemicObservational Study Published on 2022-10-012022-10-04 Journal: Research in social & administrative pharmacy : RSA [Category] 임상, [키워드] analytical sample antibiotic Antibiotic appropriateness Antibiotic prescribing Antibiotics calculated category Cohort cohorts COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients demographic characteristics Descriptive statistics Diagnosis diagnosis of COVID-19 disease severity group had no majority Mild mild COVID-19 mild COVID-19 symptoms mild symptoms moderate much lower no symptoms Non-COVID-19 non-COVID-19 cohort Non-COVID-19 patients Non-severe COVID-19 pandemic Patient patients with moderate positive positive COVID-19 proportion receiving retrospective Sample severe COVID-19. severe symptoms Symptom Symptoms use of antibiotics widespread [DOI] 10.1016/j.sapharm.2022.05.008 PMC 바로가기 [Article Type] Observational Study
Negative predictive value of procalcitonin to rule out bacterial respiratory co-infection in critical covid-19 patientsResearch article Published on 2022-10-012022-10-05 Journal: The Journal of Infection [Category] 바이오마커, 진단, [키워드] added Admission antibiotic Antibiotics association AUC Bacterial bacterial co-infection Biomarker C-reactive protein clinician Co-infection country COVID-19 COVID-19 pneumonia Critical CRP cut-off determine Diagnosis diagnostic evaluate evaluated fungal infections ICU ICU admission Logistic regression Mortality negative Negative predictive value outcome outcomes pandemic Patient patients with COVID-19 PCT Pneumonia predict Predictive procalcitonin Result retrospective cohort study secondary was performed worsening [DOI] 10.1016/j.jinf.2022.06.024 [Article Type] Research article
Development and applications of diffusive gradients in thin films for monitoring pharmaceuticals in surface watersResearch article Published on 2022-10-012022-10-05 Journal: Environmental pollution (Barking, Essex : 1987) [Category] 치료제, [키워드] antibiotic antiviral drug antiviral drugs average comparable Concentration contaminant coronavirus disease COVID-19 demonstrated development Diffusive gradients in thin films (DGT) ecological Effect exhibited Health include independent linear pharmaceutical Pharmaceuticals Previous studies provided raised reduce released required robust Treatment [DOI] 10.1016/j.envpol.2022.119979 [Article Type] Research article
Right dose, right now: bedside, real-time, data-driven, and personalised antibiotic dosing in critically ill patients with sepsis or septic shock-a two-centre randomised clinical trialRandomized Controlled Trial Published on 2022-09-052022-10-05 Journal: Critical Care [Category] 임상, [키워드] Acute kidney injury Adequate Adult patient antibiotic Antibiotics clinical Clinical decision support clinical trial control group COVID-19 pandemic Critically ill patient critically ill patients data-driven dose Efficacy eligible Endpoint EudraCT European evaluate faster feasibility feasible for inclusion ICU implementation IMPROVE incidence Inclusion increased mortality Infection intervention group Lactate Mortality Netherland not significantly different outcome patients personalised pharmacokinetic pharmacokinetics Primary outcome randomisation randomised Registered renal right Safe Sepsis Septic shock significantly Support Therapeutic Drug Monitoring Therapeutic drug monitoring. Trial was obtained [DOI] 10.1186/s13054-022-04098-7 PMC 바로가기 [Article Type] Randomized Controlled Trial
Follow-up evaluation of patients with liver test abnormalities detected during SARS-CoV2 infectionSARS-CoV2 감염 중 간검사 이상 소견이 발견된 환자에 대한 추적조사Observational Study Published on 2022-09-012022-09-11 Journal: Journal of viral hepatitis [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] Abnormalities abnormality Admission antibiotic Blood blood test coronavirus disease Coronavirus disease-19 COVID-19 criteria defined discharge disease during admission evaluated Evolution Factor Fatty liver fatty liver disease ferritin Follow-up Gender immunomodulatory individuals Infection inspired oxygen fraction liver Liver Biopsy Liver function Liver function test liver function tests male metabolic-associated fatty liver disease (MAFLD). Most patient Most patients no correlation Non-invasive observational study outcome oxygen P/F partial pressure Partial pressure of oxygen Patient patients persistent Retrospective analysis SARS-CoV2 SARS-CoV2 infection severity Treatment variable was performed [DOI] 10.1111/jvh.13718 PMC 바로가기 [Article Type] Observational Study
Tetrandrine Treatment May Improve Clinical Outcome in Patients with COVID-19Article Published on 2022-09-012022-11-15 Journal: Medicina [Category] SARS, 치료제, [키워드] antibiotic Antibiotics association China Chinese clinical Clinical outcome collected cough COVID-19 COVID-19 pandemic COVID-19 patient defined diagnosis of COVID-19 effective Effectiveness Factor fatigue group IMPROVE indicated material Medicine Mild moderate natural antiviral patients SARS-CoV-2 significant difference tetrandrine traditional Chinese medicine. treat treating COVID-19 Treatment treatment for COVID-19 were assessed with COVID-19 [DOI] 10.3390/medicina58091194 PMC 바로가기